[Radioiodine therapy for differentiated thyroid carcinoma: methods used to increase the radiation absorbed dose].

Autor:	Sapienza MT; UDDO, Serviço de Medicina Nuclear, Hospital Samaritano, São Paulo, SP. mtsapienza@hotmail.com, Endo IS, Campos Neto GC, Tavares MG, Marone MM
Jazyk:	portugalština
Zdroj:	Arquivos brasileiros de endocrinologia e metabologia [Arq Bras Endocrinol Metabol] 2005 Jun; Vol. 49 (3), pp. 341-9. Date of Electronic Publication: 2006 Mar 16.
DOI:	10.1590/s0004-27302005000300004
Abstrakt:	Objectives: Our aim was to analyze measures taken to increase the radiation absorbed dose (DOSE) during treatment of well-differentiated thyroid cancer (DTC) with iodine-131. Methods: An increase in DOSE is achieved by: avoiding competition with non-radioactive iodine, stimulating cellular uptake/retention, increasing the administered activity. Basis and results of each one of these methods were reviewed. Results: Although it is difficult to demonstrate an increase in survival, there is a direct relation between DOSE and tumoral response in DTC. Different approaches can be used aiming an increase in DOSE, with a possible improvement in tumoral response for treatment with iodine-131. Although DTC is a relatively benign disease, a better response to treatment is highly desirable in high-risk patients, who have few other options of therapy. Conclusions: An increase in DOSE during treatment of DTC can be achieved using the described interventions, which should be used in high-risk cases of DTC.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu