MTHFR C677 T gene polymorphism in lymphoproliferative diseases.
| Autor: | Deligezer U; Department of Basic Oncology, Oncology Institute, Istanbul, Turkey., Akisik EE, Yaman F, Erten N, Dalay N |
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| Jazyk: | angličtina |
| Zdroj: | Journal of clinical laboratory analysis [J Clin Lab Anal] 2006; Vol. 20 (2), pp. 37-41. |
| DOI: | 10.1002/jcla.20103 |
| Abstrakt: | Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, has been implicated in cancer risk. In the present study we used a melting curve analysis to investigate the association of the common MTHFR C677 T polymorphism with lymphoproliferative diseases. Patients (n=117) were compared with age- and sex-matched control subjects (n=154). Our results indicate that the 677 T variant occurred less frequently in patients (26%) than in the control group (33.7%; P=0.05). Investigation of the variant allele (677 T) frequency in the subgroups with Hodgkin's lymphoma (HL) and B-cell neoplasms (BCNs) revealed that this difference was a result of the significantly lower distribution of the variant allele in patients with HL (20.5%; P=0.01). This was accompanied by a significantly higher frequency of the homozygote normal genotype (677CC) among the patients with HL. In patients with BCNs the distribution of the variant allele (30.3%) was comparable to that in the control group (P=0.47). However, the difference between HL (20.5%) and BCNs (30.3%) did not reach statistical significance (P=0.09). Our results suggest that the distribution of the C677 T polymorphism may vary among lymphoproliferative diseases. ((c) 2006 Wiley-Liss, Inc.) |
| Databáze: | MEDLINE |
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