| Autor: |
van Wijk GM; Centre for Biomembranes and Lipid Enzymology, University of Utrecht, The Netherlands., Hostetler KY, van den Bosch H |
| Jazyk: |
angličtina |
| Zdroj: |
Biochimica et biophysica acta [Biochim Biophys Acta] 1991 Jul 30; Vol. 1084 (3), pp. 307-10. |
| DOI: |
10.1016/0005-2760(91)90074-r |
| Abstrakt: |
The release of the 5'-monophosphates of the antiretroviral nucleoside analogs 3'-azido-3'-deoxythymidine, 3'-deoxythymidine and 2',3'-dideoxycytidine from the corresponding nucleoside diphosphate diglycerides as a result of rat liver mitochondrial enzymatic activity is shown. The three analogs appeared to be about equally active as substrate for this pyrophosphatase activity which showed maximum conversion rates of 3-6 nmol min-1 mg protein-1 at substrate concentrations between 500 to 800 microM. These results may contribute to the biochemical explanation for the observed anti-HIV activity of this type of phospholipid conjugates in vitro. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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