The interleukin-1 beta +3953 single nucleotide polymorphism: cervical protein concentration and preterm delivery risk.
| Autor: | Edwards RK; Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL 32610-0294, USA. edwardsr@obgyn.ufl.edu, Ferguson RJ, Duff P |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2006 Apr; Vol. 55 (4), pp. 259-64. |
| DOI: | 10.1111/j.1600-0897.2005.00358.x |
| Abstrakt: | Problem: To determine the associations between preterm delivery <37 weeks (PTD), cervical fluid interleukin-1beta (IL-1beta) concentration, and its +3953 single nucleotide polymorphism (SNP). Method of Study: Cervical fluid, peripheral blood, and cord blood samples were obtained from a cohort of women 23-32 weeks gestation with preterm labor symptoms and intact membranes. Results: Increased cervical fluid concentrations of IL-1beta were associated with PTD (P = 0.017) and spontaneous PTD (P = 0.001). Maternal IL-1beta +3953 SNP genotype was associated neither with PTD (P = 0.43) nor with cervical fluid IL-1beta concentrations (P = 0.35). Neonatal IL-1beta +3953 SNP genotype was associated neither with PTD nor cervical IL-1beta concentrations. Conclusions: Cervical fluid concentrations of IL-1beta were elevated in symptomatic women destined to have a spontaneous PTD. The gene dosage of maternal IL-1beta +3953 allele 2 was associated neither with increased cervical fluid concentrations of IL-1beta nor with risk of PTD. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|