| Autor: |
Prescott JH; MicroCHIPS Inc., 6-B Preston Court, Bedford, Massachusetts 01730, USA., Lipka S, Baldwin S, Sheppard NF Jr, Maloney JM, Coppeta J, Yomtov B, Staples MA, Santini JT Jr |
| Jazyk: |
angličtina |
| Zdroj: |
Nature biotechnology [Nat Biotechnol] 2006 Apr; Vol. 24 (4), pp. 437-8. Date of Electronic Publication: 2006 Mar 12. |
| DOI: |
10.1038/nbt1199 |
| Abstrakt: |
Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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