| Autor: |
An HJ; College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, 1-Hoegi-Dong, Dongdaemun-Gu, Seoul 130-701, Republic of Korea., Jeong HJ, Um JY, Kim HM, Hong SH |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of ethnopharmacology [J Ethnopharmacol] 2006 Jul 19; Vol. 106 (3), pp. 418-24. Date of Electronic Publication: 2006 Mar 10. |
| DOI: |
10.1016/j.jep.2006.01.024 |
| Abstrakt: |
Glechoma hederacea (GH) is an herb widely used herb medicine for the treatment of a variety of pathologies. In this study, the effect of GH on interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS)-induced production of nitric oxide (NO), interleukin (IL)-12p70, IL-12p40, tumor necrosis factor-alpha (TNF-alpha), and IL-6 were examined using mouse peritoneal macrophages. GH inhibits IFN-gamma/LPS-induced NO in a dose-dependent manner. The decrease in NO synthesis was reflected as a decreased amount of inducible NO synthase protein. We also found that GH inhibits pro-inflammatory cytokine, IL-12p70, and TNF-alpha production. However, GH increased IFN-gamma/LPS-induced IL-12p40 production. GH doesn't affect the IL-6 production. These findings mean that GH can be used in controlling macrophages mediated inflammation related disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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