| Autor: |
Konnov BA, Konnova LA, Lebedeva NA, Shalek RA |
| Jazyk: |
ruština |
| Zdroj: |
Meditsinskaia radiologiia [Med Radiol (Mosk)] 1991; Vol. 36 (7), pp. 16-8. |
| Abstrakt: |
The composition and blood concentration of free aminoacids and other aminocompounds were investigated using automatic aminoacid analysis by a physiological program in 12 patients with diagnosed corticotropin secreting hypophyseal disease (Itsenko-Cushing disease) before and 1-3 years after proton "hypophysectomy". Imbalance of components of the glucose-alanine cycle, expressed in hypoalaninemia and raised concentration of aminoacids with a bifurcated lateral chain, was detected against a background of marked hypercorticotropinemia and hypercorticolism. Single irradiation of the pituitary gland with a proton beam at absorbed doses of 100-120 Gy in the maximum of a deep field resulted in remission and normalization of aminograms of blood plasma (suggesting pathogenicity of proton-beam therapy) for 6-12 mos. The authors discussed probable mechanisms of the interrelationship of protein-amino-acid and carbohydrate metabolic derangements and their correlation with a type of changes in the hormonal balance. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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