| Autor: |
MacPhee AA, Cole FE, Rice BF |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 1975 Apr; Vol. 40 (4), pp. 688-96. |
| DOI: |
10.1210/jcem-40-4-688 |
| Abstrakt: |
Melatonin stimulated steroidogenesis in two compartments of the human ovary in vitro. In a corpus luteum of the menstrual cycle, melatonin increased progesterone synthesis in a dose related manner. Both serotonin and N-acetyl serotonin had no effect on progesterone synthesis. In the ovarian stroma, melatonin stimulated the incorporation of acetate-1-14-C into androstenedione. Binding of radioactive hCG by the corpus luteum was unaffected by melatonin. No specific binding of radioactive melatonin of low specific activity could be detected in homogenates of a human corpus luteum. These observations suggest that melatonin may directly modulate steroidogenesis in the human ovary. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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