| Autor: |
Ganem YJ; Service de Biochimie et Neurobiologie, Hôpital Saint-Louis, Paris, France., Launay JM, Debons-Guillemin MC, Lasneret J, Roucayrol AM, Lesser J, Peries G, Dreux C |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer [Cancer] 1991 Aug 15; Vol. 68 (4), pp. 893-902. |
| DOI: |
10.1002/1097-0142(19910815)68:4<893::aid-cncr2820680436>3.0.co;2-e |
| Abstrakt: |
The first successful heterotransplantation of a human carcinoid tumor into nude mice is reported. CSH, a voluminous hepatic metastasis of a primary bronchial carcinoid tumor (CSB) was resected and transplanted into three irradiated nude (Swiss-nu/nu) mice both by subcutaneous (SC) and intramuscular (IM) routes; the success rate was five of six. Heterotransplanted tumors took 4 to 5 months to appear in the mice and 1 month to attain a width of 0.5 cm. Both human and mouse tumors (named CSH-SC and CSH-IM) were studied by light and electron microscopy. They were Grimelius-positive, neuron-specific enolase-positive, and bombesin-negative by immunocytochemistry. Furthermore, CSH-SC cells presented characteristic (pear-shaped, rod-shaped, or tadpole-shaped) neurosecretory granules. Although CSB and CSH were slightly serotonin positive by immunocytochemistry, only a few serotonin-positive cells were found in CSH-SC and none in CSH-IM, suggesting partial loss of differentiation or an increase in serotonin catabolism during transplantation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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