| Autor: |
Aubry C; Department of Chemistry, University of Leicester, Leicester LE1 7RH, UK. kin@le.ac.uk, Wilson AJ, Jenkins PR, Mahale S, Chaudhuri B, Maréchal JD, Sutcliffe MJ |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2006 Mar 07; Vol. 4 (5), pp. 787-801. Date of Electronic Publication: 2006 Feb 01. |
| DOI: |
10.1039/b518019h |
| Abstrakt: |
We present the design, synthesis, and biological activity of three classes of tryptamine derivatives, which are non-planar analogues of the toxic anti-cancer agent fascaplysin. We show these compounds to be selective inhibitors of CDK4 over CDK2, the most active compound has an IC50 for the inhibition of CDK4 of 6 microM. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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