Leucocyte-depleting arterial line filtration does not reduce myocardial injury assessed by Troponin T during routine coronary artery bypass grafting using crossclamp fibrillation.
| Autor: | Whitaker DC; Centre for Behavioural and Social Sciences in Medicine, University College London, London, UK., Stygall J, Harrison MJ, Mackie IJ, Kemp M, Hooper J, Pugsley WB, Newman SP |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Perfusion [Perfusion] 2006 Jan; Vol. 21 (1), pp. 55-60. |
| DOI: | 10.1191/0267659106pf847oa |
| Abstrakt: | Introduction: Leucocyte filtration can reduce inflammation and end-organ damage. The aim of this study was to test the cardioprotective effect of systemic leucocyte filtration during cardiopulmonary bypass (CPB) for coronary revascularization. Methods: Sixty patients scheduled for elective coronary artery bypass grafting were prospectively randomised to receive either a test leucocyte-depleting (LD) filter or a control standard arterial line filter in the CPB circuit. Myocardial injury was determined by serum Troponin T concentration up to 72 h postoperatively. In addition, perioperative neutrophil counts, serum elastase and electrocardio-grams (ECGs) were evaluated. Results: There was a peak of Troponin T release at 6 h in both groups. There was no difference between LD or control group Troponin T at any time point. No difference in neutrophil count was found. A greater rise in neutrophil elastase occurred in the LD group during CPB and 10 min post CPB (376 and 496 versus 108 and 228 mcg/L, p<0.001). Conclusions: LD arterial line filters did not confer any cardioprotective effect as measured by Troponin T in elective coronary revascularization cases. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|