| Autor: |
Shearman AM; Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. shearman@mit.edu, Cooper JA, Kotwinski PJ, Miller GJ, Humphries SE, Ardlie KG, Jordan B, Irenze K, Lunetta KL, Schuit SC, Uitterlinden AG, Pols HA, Demissie S, Cupples LA, Mendelsohn ME, Levy D, Housman DE |
| Jazyk: |
angličtina |
| Zdroj: |
Circulation research [Circ Res] 2006 Mar 17; Vol. 98 (5), pp. 590-2. Date of Electronic Publication: 2006 Feb 16. |
| DOI: |
10.1161/01.RES.0000210578.62102.a6 |
| Abstrakt: |
Understanding the mechanisms by which estrogens affect cardiovascular disease risk, including the role of variation in the gene for estrogen receptor alpha (ESR1), may be key to new treatment strategies. We investigated whether the CC genotype at ESR1 c.454-397T>C is associated with increased risk among men. Study of more than 7000 whites in 5 cohorts from 4 countries provided evidence that genotype CC, present in roughly 20% of individuals, is a risk factor for nonfatal acute myocardial infarction (odds ratio=1.44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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