| Autor: |
Cunha AB; Department of Neuropsychiatry, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Faixa de Camobi Km 9, 97105 900 Santa Maria, RS, Brazil., Frey BN, Andreazza AC, Goi JD, Rosa AR, Gonçalves CA, Santin A, Kapczinski F |
| Jazyk: |
angličtina |
| Zdroj: |
Neuroscience letters [Neurosci Lett] 2006 May 08; Vol. 398 (3), pp. 215-9. Date of Electronic Publication: 2006 Feb 09. |
| DOI: |
10.1016/j.neulet.2005.12.085 |
| Abstrakt: |
Genetic and pharmacological studies have suggested that brain-derived neurotrophic factor (BDNF) may be associated with the pathophysiology of bipolar disorder (BD). The present study investigated serum BDNF levels in manic, depressed, euthymic BD patients and in matched healthy controls, using an enzyme-linked immunosorbent assay (sandwich-ELISA). Serum BDNF levels were decreased in manic (p=0.019) and depressed (p=0.027) BD patients, as compared with euthymic patients and controls. Serum BDNF levels were negatively correlated with the severity of manic (r=-0.37, p=0.005) and depressive (r=-0.30, p=0.033) symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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