| Autor: |
Godley PJ; University of Texas, Austin., Moore ES, Woodworth JR, Fineg J |
| Jazyk: |
angličtina |
| Zdroj: |
Biopharmaceutics & drug disposition [Biopharm Drug Dispos] 1991 Apr; Vol. 12 (3), pp. 189-99. |
| DOI: |
10.1002/bdd.2510120303 |
| Abstrakt: |
A three-way crossover study was performed to determine the influence of delta 9-tetrahydrocannabinol (THC) and ethanol (EtOH) separately upon phencyclidine (PCP) disposition in dogs. Seven dogs were given three single dose treatments: 1.5 mg PCP kg-1 i.v., 1.5 mg PCP kg-1 i.v. with 0.4 mg kg-1 THC i.v., and 1.5 mg PCP kg-1 i.v. with 1.25 g EtOH kg-1 i.v. PCP was measured in plasma samples collected for 24 h after administration of each treatment, with several pharmacokinetic parameters calculated from the plasma concentration vs time data. The PCP serum Cls values were significant change in V beta or t1/2. EtOH did not induce significant changes in any PCP pharmacokinetic parameter, although mean Cls and V beta were increased. These results confirm the observed THC inhibition of PCP metabolism, and suggest that the enhanced pharmacologic action of PCP by THC may result from higher serum PCP concentrations. These results further suggest that enhanced PCP actions by acute EtOH administration may result from increased PCP distribution to the CNS. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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