[Alpha1 desensitization of the heart during adaptation to stress].

Autor: Meerson FZ, Kopylov IuN, Baldenkov GN
Jazyk: ruština
Zdroj: Fiziologicheskii zhurnal [Fiziol Zh (1978)] 1991 Jan-Feb; Vol. 37 (1), pp. 3-6.
Abstrakt: Results of the experiments evidence that a combination of three factors, limiting the Ca2+ concentration increase in myocardial cell, can play a role in the cardioprotective effect of adaptation of rats to short-term immobilization stress (every second day for a month) are presented. Those factors are as follows: desensitization of alpha 1-adrenoreceptors, M-cholinoreceptors up-regulation and reduced number of voltage-dependent Ca2+ channels in the myocardial membranes.
Databáze: MEDLINE