| Autor: |
Dougherty AM; Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA., McDonald FE, Liotta DC, Moody SJ, Pallas DC, Pack CD, Merrill AH |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2006 Feb 16; Vol. 8 (4), pp. 649-52. |
| DOI: |
10.1021/ol052839v |
| Abstrakt: |
[structure: see text] A family of cyclic 1-deoxysphingolipid derivatives of structure 4 has been designed and synthesized, which may serve as tumorigenesis suppressors for various cancers. Compound 4 is a second-generation analogue developed from sphingosine (1), in which a hydroxyl substituent is moved from C1 to C5 and a methylene is added for conformational rigidity between the C2-nitrogen substituent and C4. The synthetic chemistry for pyrrolidine ring closure at C3-C4 features ring-closing metathesis followed by hydroboration-oxidation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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