| Autor: |
Gamberini MR; Department of Reproduction and Growth, Paediatric and Adolescent Unit, S. Anna Hospital, Ferrara, Italy. mr.gamberini@libero.it, Fortini M, De Sanctis V |
| Jazyk: |
angličtina |
| Zdroj: |
Pediatric endocrinology reviews : PER [Pediatr Endocrinol Rev] 2004 Dec; Vol. 2 Suppl 2, pp. 316-8. |
| Abstrakt: |
We report a 24 years old patient with thalassaemia intermedia and gynecomastia, complicated by paraplegia and urinary/fecal incontinence due to spinal cord compression by an extramedullary erythropoiesis (EE) mass, treated with long-term hydroxyurea (HU). Neurological improvement occurred during the first 6 weeks of HU therapy (1,000 mg/day) and magnetic resonance imaging showed a reduction in EE mass. HU dosage was reduced to 500 mg/day after 5 months, and treatment was discontinued after 25 months. Five months later there was a partial recurrence of neurological symptoms, which responded to radiotherapy. HU may have a role in the symptomatic treatment of spinal cord compression due to EE, particularly when radiotherapy is unavailable. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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