| Autor: |
Yurasov S; Laboratory of Molecular Immunology, The Rockefeller University, 1230 York Ave., New York, NY 10021, USA., Hammersen J, Tiller T, Tsuiji M, Wardemann H |
| Jazyk: |
angličtina |
| Zdroj: |
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2005 Dec; Vol. 1062, pp. 165-74. |
| DOI: |
10.1196/annals.1358.019 |
| Abstrakt: |
Antibodies are protective effector molecules in the body's immune defense against pathogens. However, if directed against the body's own tissues or organs, antibodies can also play a role in the pathogenesis of autoimmune disease. Here, we discuss our data on how autoreactive antibodies are regulated in healthy humans and how a failure to establish self-tolerance during early B-cell development in patients with systemic lupus erythematosus may predispose to the development of this autoimmune disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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