| Autor: |
Hinds MT; Department of Biomedical Engineering, Oregon Health and Science University, Portland, 97006, USA. monica.hinds@bme.ogi.edu, Rowe RC, Ren Z, Teach J, Wu PC, Kirkpatrick SJ, Breneman KD, Gregory KW, Courtman DW |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2006 Jun 01; Vol. 77 (3), pp. 458-69. |
| DOI: |
10.1002/jbm.a.30571 |
| Abstrakt: |
Elastin, a principal structural component of native arteries, has distinct biological and mechanical advantages when used as a biomaterial; however, its low ultimate tensile strength has limited its use as an arterial conduit. We have developed a scaffold, consisting of a purified elastin tubular conduit strengthened with fibrin bonded layers of acellular small intestinal submucosa (aSIS) for potential use as a small diameter vascular graft. The addition of aSIS increased the ultimate tensile strength of the elastin conduits nine-fold. Burst pressures for the elastin composite vascular scaffold (1,396 +/- 309 mmHg) were significantly higher than pure elastin conduits (162 +/- 36 mmHg) and comparable to native saphenous veins. The average suture pullout strength of the elastin composite vascular scaffolds was 14.612 +/- 3.677 N, significantly higher than the pure elastin conduit (0.402 +/- 0.098 N), but comparable to native porcine carotid arteries (13.994 +/- 4.344 N). Cyclic circumferential strain testing indicated that the composite scaffolds were capable of withstanding physiological loading conditions for at least 83 h. Implantation of the elastin composites as carotid interposition grafts in swine demonstrated its superiority to clinically acceptable ePTFE with significantly longer average patency times of 5.23 h compared to 4.15 h. We have developed a biologically based elastin scaffold with suitable mechanical properties and low thrombogenicity for in vivo implantation, and with the potential for cellular repopulation and host integration reestablishing an appropriate elastic artery. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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