| Autor: |
Mansoor TA; College of Pharmacy, Pusan National University, Busan 609-735, Korea., Lee YM, Hong J, Lee CO, Im KS, Jung JH |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2006 Jan; Vol. 69 (1), pp. 131-4. |
| DOI: |
10.1021/np0502950 |
| Abstrakt: |
Four new (1, 2, 4, and 5) and 14 known (3 and 6-18) polyoxygenated sterols have been isolated from the MeOH extract of the marine sponge Homaxinella sp. by bioactivity-guided fractionation. The planar structures of the sterols were established by 1D and 2D NMR and MS spectroscopic analysis. 5,6:8,9-Diepoxy sterols (1-3) were isolated from a marine organism for the first time. The isolated sterols were tested against a panel of five human solid tumor cell lines and exhibited varying degrees of cytotoxicity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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