Efficient synthesis of [2-15N]guanosine and 2'-deoxy[2'-15N]guanosine derivatives using N-(tert-butyldimethylsilyl)[15N]phthalimide as a 15N-labeling reagent.

Autor:	Kamaike K; School of Pharmarcy, Tokyo University of Pharmarcy and Life Sciences, Hachioji, Tokyo, Japan. kamaikek@ps.toyaku.ac.jp, Kayama Y, Mitsuhisa I, Etsuko K
Jazyk:	angličtina
Zdroj:	Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2006; Vol. 25 (1), pp. 29-35.
DOI:	10.1080/15257770500377771
Abstrakt:	Nucleophilic aromatic substitution of 9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-6-chloro-2-fluoro-9H-purine with N-(tert-butyldimethylsilyl) [15N]phthalimide in the presence of a catalytic amount of CsF at room temperature in DMF efficiently afforded the 6-chloro-2-[15N]phthalimidopurine derivative, which was subsequently converted to the [2-15N]guanosine derivative. The 2'-deoxy[2'-15N]guanosine derivative was also efficiently synthesized through a similar procedure.
Databáze:	MEDLINE
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