| Autor: |
Krause W; Department of Andrology and Venerology, University Hospital, Philipp University, Deutschhausstr. 9, D-35033 Marburg, Germany. krause@med.uni-marburg.de, Krisp A, Hörster S, Hoffmann R |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of dermatology : EJD [Eur J Dermatol] 2006 Jan-Feb; Vol. 16 (1), pp. 75-8. |
| Abstrakt: |
Pagetoid cells are large intraepidermal cells which spread intraepidermally. We report a 67-year old Caucasian male, who presented for the first time in 1993 with a long-standing pruritic lesion at the scrotum. He was treated for several years by antiinflammatory ointments. Only in July 2003 was a biopsy taken for the first time. The histopathological evaluation revealed the diagnosis of an extramammary Paget's disease (EMPD). Pagetoid cells are large intraepidermal cells with a large nucleus and ample cytoplasm. EMPD consists of primary malignant cells of epidermal origin, but in rare cases, pagetoid cells may also originate from carcinomas with epidermotropic growth. EMPD is a slowly progressing disease, but invading and metastasing tumors may also develop. Considering the good prognosis with long-term survival, nonsurgical modalities should be considered as primary treatment for noninvasive EMPD. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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