| Autor: |
Furegati S; Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland., Gorla F, Linden A, Rüedi P |
| Jazyk: |
angličtina |
| Zdroj: |
Chemico-biological interactions [Chem Biol Interact] 2005 Dec 15; Vol. 157-158, pp. 415-7. |
| DOI: |
10.1016/j.cbi.2005.10.084 |
| Abstrakt: |
The novel decalin-type N,O,P-heterocycles, P(3)-axially and P(3)-equatorially substituted cis- and trans-configurated 3-fluoro-2,4-dioxa-7-aza-, 2,4-dioxa-8-aza-, and 2,4-dioxa-9-aza-3-phosphabicyclo[4.4.0]decane 3-oxides, are configuratively fixed and conformationally constrained phosphorus analogues of acetylcholine. The compounds are suitable probes for the investigation of molecular interactions with acetylcholinesterase. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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