| Autor: |
Matthai C; Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Waehringer Guertel, Vienna, Austria., Horvat R, Noe M, Nagele F, Radjabi A, van Trotsenburg M, Huber J, Kolbus A |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular human reproduction [Mol Hum Reprod] 2006 Jan; Vol. 12 (1), pp. 7-10. Date of Electronic Publication: 2006 Jan 18. |
| DOI: |
10.1093/molehr/gah254 |
| Abstrakt: |
The transcription factor Oct-4 is crucial for the maintenance of cell pluripotency and is known to be expressed in embryonic stem cells, germ cells and whole embryos at various stages of development. Oct-4 regulates cell fate in a dose-dependent manner and plays a key role in germ-cell tumours. In the past, several stem-cell markers have been detected, and their role in the pathogenesis of diseases has been discussed frequently. Thus, we investigated the expression of Oct-4 comparing its occurrence in endometrium of healthy and diseased women using immunohistochemistry (IHC) and RT-PCR. IHC demonstrated Oct-4 expression in 25 of 60 sections (42%), respectively in 11 out of 25 patients (44%). Oct-4 mRNA was detected by RT-PCR in all tested samples (9 of 9) of endometrium, although the levels of expression varied. To our knowledge, this is the first study demonstrating Oct-4 expression in human endometrium. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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