| Autor: |
Rodríguez ME; CINDEFI, Faculty of Science, La Plata University, calles 47 y 115, 1900 La Plata, Argentina. mer@quimica.unlp.edu.ar, Hellwig SM, Pérez Vidakovics ML, Berbers GA, van de Winkel JG |
| Jazyk: |
angličtina |
| Zdroj: |
FEMS immunology and medical microbiology [FEMS Immunol Med Microbiol] 2006 Feb; Vol. 46 (1), pp. 39-47. |
| DOI: |
10.1111/j.1574-695X.2005.00001.x |
| Abstrakt: |
Bordetella pertussis attachment to host cells is a crucial step in colonization. In this study, we investigated the specificity of antibodies, induced either by vaccination or infection, capable of reducing bacterial adherence to respiratory epithelial cells. Both sera and purified anti-B. pertussis IgG or IgA fractions efficiently reduced attachment. This effect was found to be mediated mainly by fimbriae-specific antibodies. Antibodies with other specificities did not significantly interfere in the interaction of B. pertussis with respiratory epithelial cells, with the exception of antifilamentous hemaglutinin antibodies, which reduced bacterial attachment. However, this effect was smaller in magnitude than that observed in the presence of fimbriae-specific antibodies. The strong agglutinating activity of antifimbriae antibodies seems to be involved in this phenomenon. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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