| Autor: |
Kruman II, Matylevich NP, Rochev IuA, Beletskiĭ IP, Afanas'ev VN, Umanskiĭ SR |
| Jazyk: |
ruština |
| Zdroj: |
Tsitologiia [Tsitologiia] 1992; Vol. 34 (2), pp. 43-53. |
| Abstrakt: |
By flow cytometry, imitation modelling and biochemical analysis, the mode and kinetics of dexamethasone-treated T-lymphoma cell death were studied. The hormone was shown to induce delays in pre- and postsynthetic phases of the cell cycle and the death of part of cells. A short exposure to dexamethasone reveals its cytostatic rather than cytolytic effect. Following G2/M delay and cytokinesis, part of cells dies. A reduced serum concentration (2%) causes shorter delays in the cell cycle and a more rapid cell death. Dexamethasone stimulates apoptosis which is indicated by internucleosomal DNA fragmentation, and by a coincidence in time of the processes of DNA degradation and increase in the other membrane permeability. These results are discussed in relation to the cell death and proliferation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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