| Autor: |
Smith ED; Department of Chemistry, North Carolina State University, Raleigh, 27695-8204, USA., Février FC, Comins DL |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2006 Jan 19; Vol. 8 (2), pp. 179-82. |
| DOI: |
10.1021/ol052099q |
| Abstrakt: |
[reaction: see text] A variety of novel nicotine derivatives were prepared via reductive disilylation of (S)-nicotine. Treatment of nicotine with lithium powder and chlorotrimethylsilane afforded 1,4-bis(trimethylsilyl)-1,4-dihydronicotine in high yield. Addition of various carbonyl electrophiles and a catalytic amount of TBAF provided either C-5 substituted nicotines or 1,4-dihydronicotine derivatives. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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