| Autor: |
Flatters SJ; Department of Anaesthesia, McGill University, Montreal, Que., Canada. sflatters@zeus.bwh.harvard.edu, Xiao WH, Bennett GJ |
| Jazyk: |
angličtina |
| Zdroj: |
Neuroscience letters [Neurosci Lett] 2006 Apr 24; Vol. 397 (3), pp. 219-23. Date of Electronic Publication: 2006 Jan 06. |
| DOI: |
10.1016/j.neulet.2005.12.013 |
| Abstrakt: |
This study examines the potential efficacy of acetyl-L-carnitine (ALC) to prevent and treat paclitaxel-induced pain. Rats received four intraperitoneal (i.p.) injections of 2 mg/kg paclitaxel on alternate days which, following a short delay induced marked mechanical hypersensitivity. Daily administration of ALC (50 mg/kg and 100 mg/kg; p.o.; concurrently with paclitaxel and for 14 days afterwards) prevented the development of paclitaxel-induced pain. This effect was long lasting, for at least 3 weeks after the last dose of ALC. In a separate experiment, daily administration of ALC (100 mg/kg; p.o.; for 10 days) to rats with established paclitaxel-induced pain produced an analgesic effect. This effect dissipated shortly after ALC treatment was withdrawn. We conclude that ALC may be useful in the prevention and treatment of chemotherapy-induced painful peripheral neuropathy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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