An efficient synthesis of new C-2 aryl substituted quinolines based on three component imino Diels-Alder reaction.

Autor: Kouznetsov VV; Laboratorio de Química Orgánica y Biomolecular, Escuela de Química, Universidad Industrial de Santander, A.A. 678, Bucaramanga, Colombia. kouznet@uis.edu.co, Bohórquez AR, Saavedra LA, Medina RF
Jazyk: angličtina
Zdroj: Molecular diversity [Mol Divers] 2006 Feb; Vol. 10 (1), pp. 29-37.
DOI: 10.1007/s11030-006-2344-8
Abstrakt: New effective approach to the synthesis of a wide variety of C-2 nitro or aminophenyl substituted quinolines was reported using diverse intermediate 4-(2-oxopyrrolinidyl-1)-tetrahydroquinolines that were prepared by a three component imino Diels-Alder reaction was reported. The key aromatisation process occurs cleanly with the loss of the 2-oxopyrrolinidyl-1 fragment.
Databáze: MEDLINE
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