Current concepts for the surgical management of carotid body tumor.

Autor: Knight TT Jr; Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, P. O. Box 70575, Johnson City, TN 37614, USA. knighttt@etsu.edu, Gonzalez JA, Rary JM, Rush DS
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 2006 Jan; Vol. 191 (1), pp. 104-10.
DOI: 10.1016/j.amjsurg.2005.10.010
Abstrakt: Background: Carotid body tumor (CBT) is a rare lesion of the neuroendocrine system. Chronic hypoxia has long been recognized as an etiology of CBT and other paragangliomas. Recent biogenetic discoveries reveal that mutations in oxygen-sensing genes are another etiology, accounting for approximately 35% of cases, and that these 2 etiologies are probably additive.
Data Sources: (1) A retrospective analysis of fifteen cases of CBT in a 6-year period occurring in the mountains of Southern Appalachia; (2) an extensive review of the literature on the surgery of CBT and on the expansive biogenetic understanding of the disease.
Conclusions: Improved imaging, vascular surgical techniques, and understanding of the disease have vastly improved outcomes for patients. The necessities for long-term follow-up and appropriate genetic testing and counseling of patients and their families are documented. Surgeon and institutional competence are critical in achieving maximal outcomes.
Databáze: MEDLINE