European multi-centre study on coeliac disease and non-Hodgkin lymphoma.
| Autor: | Mearin ML; Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands. m.l.mearin_manrique@lumc.nl, Catassi C, Brousse N, Brand R, Collin P, Fabiani E, Schweizer JJ, Abuzakouk M, Szajewska H, Hallert C, Farré Masip C, Holmes GK |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2006 Feb; Vol. 18 (2), pp. 187-94. |
| DOI: | 10.1097/00042737-200602000-00012 |
| Abstrakt: | Introduction: Coeliac disease (CD) is associated with an increased risk of non-Hodgkin lymphoma (NHL), but there is little information about whether this is true for clinically silent CD. Objective: To investigate the frequency of CD in two European populations; one with NHL and another derived from the general population. Methods: A prospective, multi-centre, case-control study in 10 European countries was conducted between May 1998 and April 2001. A total of 1446 consecutive patients with newly diagnosed NHL aged over 18 years was collected. The control group consisted of a population of 9676 individuals who were screened for CD. The number of patients with a previous diagnosis of CD and those with silent CD detected by screening were determined in the two groups. Results: The patients with CD had a significantly increased risk of developing NHL [odds ratio (OR) 2.6, 95% confidence interval (CI) 1.4-4.9]. This risk was only present in patients with CD diagnosed clinically before the study (OR 3.3, 95% CI 1.4-7.9), but not in those with silent CD detected by screening (OR 1.3, 95% CI 0.6-2.7). Conclusion: Patients with CD have an increased risk of developing NHL, although this is lower than previously thought. Clinically silent CD is rare in patients with NHL. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|