| Autor: |
Plagemann A; Institute of Experimental Endocrinology, Humboldt University Medical School (Charité), Berlin/Germany., Heidrich I, Götz F, Rohde W, Dörner G |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental and clinical endocrinology [Exp Clin Endocrinol] 1992; Vol. 99 (2), pp. 91-5. |
| DOI: |
10.1055/s-0029-1211143 |
| Abstrakt: |
Newborn male Wistar-rats received bilateral intrahypothalamic insulin-agar-implants on the 2nd or 8th day of life. In male control animals only the insulin-free indifferent agar-vehicle was implanted at the same age. In both experimental groups with temporary intrahypothalamic hyperinsulinism during brain organization the following results were obtained: 1) Higher body weight gain starting at the end of the hypothalamic differentiation period and continuing during juvenile life until adulthood, resulting in increased relative body weight as a sign of obesity; 2) A tendency to basal hyperinsulinaemia in juvenile and adult age; 3) Impaired glucose tolerance in adulthood; 4) Increased diabetes susceptibility to a single "subdiabetogenic" dose of streptozotocin in adult age. In view of these and previous observations a teratogenetic role of high insulin concentrations during the organization of glucoregulatory hypothalamic structures is hypothesized and the possible relevance of such hyperinsulinism as a predisposing factor for a lifelong enhanced diabetes and/or obesity risk is suggested. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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