| Autor: |
Wijchers PJ; Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands., Hoekman MF, Burbach JP, Smidt MP |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research [Brain Res] 2006 Jan 12; Vol. 1068 (1), pp. 23-33. Date of Electronic Publication: 2005 Dec 27. |
| DOI: |
10.1016/j.brainres.2005.11.022 |
| Abstrakt: |
The murine forkhead family of transcription factors consists of over 30 members, the vast majority of which is important in embryonic development. Implicated in processes such as proliferation, differentiation and survival, forkhead factors show highly restricted expression patterns. In search for forkhead genes expressed in specific neural systems, we identified multiple family members. We performed a detailed expression analysis for Foxj2, Foxk1 and the murine orthologue of the human ILF1 gene, which show a remarkable preference for complex cortical structures. In addition, a comprehensive examination of forkhead gene expression in dopamine neurons of the ventral tegmental area and substantia nigra pars compacta, revealed Ilf1 as a novel transcriptional regulator in midbrain dopamine neurons. These forkhead transcription factors may play a role in maintenance and survival of developing and adult neurons. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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