| Autor: |
Rojas-Martínez A; Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, México., Vázquez-Alemán RM, Gustincich S, Cantú JM, Barrera-Saldaña HA |
| Jazyk: |
Spanish; Castilian |
| Zdroj: |
Boletin medico del Hospital Infantil de Mexico [Bol Med Hosp Infant Mex] 1992 Jun; Vol. 49 (6), pp. 335-41. |
| Abstrakt: |
We have initiated the screening of the delta F508 cystic fibrosis (CF) mutation in our country basing our study on the polymerase chain reaction technique. In a sample of 10 western and a northeastern Mexican families that have at least one CF affected child, we found a delta F508 frequency of 59.1% among CF chromosomes. This frequency is similar to those reported for Spain. Furthermore, we found a correlation between the delta F508 allele and pancreatic insufficiency. This paper points out the advantage of the polymerase chain reaction technology for the analysis of Mendelian disorders. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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