| Autor: |
Sharonova NI; Brain Research Institute, Russian Academy of Medical Sciences, Moscow., Vorob'ev VS, Skrebitskii VG, Galenko-Yaroshevskii AP, Turovaya AY, Anisimova VA |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2005 Sep; Vol. 140 (3), pp. 326-9. |
| DOI: |
10.1007/s10517-005-0481-1 |
| Abstrakt: |
Voltage clamp and concentration jump experiments performed on Purkinje cells isolated from rat cerebellum showed that novel imidazobenzoimidazole derivative RU-353 increased the amplitude of GABA-activated chlorine current in a dose-dependent manner (EC50=15 microM for the currents activated by 1 microM GABA). RU-353 shifted the GABA dose-response curve to the left, but produced no effect on the maximum response (EC50 in control and in the presence of 30 microM RU-353 were 6.9 and 2.0 microM, respectively). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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