| Autor: |
van den Hoogenband A; Solvay Pharmaceuticals, Research Laboratories, C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands., van Maarseveen JH, McCreary AC, Mulder AT, van Scharrenburg GJ, van Stuivenberg HH, Zethof TJ, Zijta B, Iwema Bakker WI |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Feb 15; Vol. 16 (4), pp. 1045-8. Date of Electronic Publication: 2005 Nov 11. |
| DOI: |
10.1016/j.bmcl.2005.10.077 |
| Abstrakt: |
The synthesis and structure-activity relations for a new class of centrally active NK-1 receptor antagonists are described. The new compounds are based on piperazine 2 and contain an oxime ether functionality. Several new compounds have high affinity for the NK-1 receptor and show good antagonistic activity in the gerbil foot-tapping assay. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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