Regioselective C-2 and C-6 substitution of (S)-nicotine and nicotine derivatives.

Autor: Février FC; Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA., Smith ED, Comins DL
Jazyk: angličtina
Zdroj: Organic letters [Org Lett] 2005 Nov 24; Vol. 7 (24), pp. 5457-60.
DOI: 10.1021/ol052196j
Abstrakt: [reaction: see text] Regioselective deprotonations of (S)-nicotine and derivatives at the C-2 and C-6 positions of the pyridine ring were performed in good to excellent yields. These methodologies allow the direct introduction of a plethora of functional groups onto the pyridine ring of nicotine.
Databáze: MEDLINE