Identification of serovar-specific single-nucleotide polymorphisms of C. Trachomatis omp1 gene.

Autor: Sharkeev VI; Institute of Physicochemical Medicine, Ministry of Health of Russian Federation, Moscow., Torshin IY, Shkarupeta MM, Akopian TA, Lazarev VN, Govorun VM
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2005 Aug; Vol. 140 (2), pp. 222-7.
DOI: 10.1007/s10517-005-0451-7
Abstrakt: Complete sequences of omp1 gene encoding chlamydial main outer membrane protein were analyzed in 76 clinical strains of C. trachomatis. Thirty-four serovar-specific single-nucleotide polymorphisms were identified, 20 of them meet two criteria: unique position of the nucleotide and unique nucleotide substitution. Evaluation of serovar-specific single-nucleotide polymorphisms of omp1 gene can appreciably simplify and accelerate genetic diagnosis of C. trachomatis serovars.
Databáze: MEDLINE