Mature subcutaneous and visceral adipocyte concentrations of adiponectin are highly correlated in prepubertal children and inversely related to body mass index standard deviation score.
| Autor: | Sabin MA; Department of Pediatric Endocrinology and Metabolism, Institute of Child Health, Royal Hospital for Children, Bristol BS2 8AE, United Kingdom. mattsabin@doctors.org.uk, Holly JM, Shield JP, Turner SJ, Grohmann MJ, Stewart CE, Crowne EC |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2006 Jan; Vol. 91 (1), pp. 332-5. Date of Electronic Publication: 2005 Oct 25. |
| DOI: | 10.1210/jc.2005-1571 |
| Abstrakt: | Context: Adiponectin is an adipocyte-specific protein with insulin-sensitizing properties. Several studies have examined the expression of adiponectin mRNA or tissue/secreted protein levels in fat obtained from adults, but none has assessed tissue levels in childhood. Patients: Paired subcutaneous (Sc) and visceral (V) fat samples were obtained from 12 normal-weight children. Main Outcome Measures: Mature adipocytes were isolated and total adiponectin levels determined by ELISA. Insulin sensitivity and lipid parameters were assessed in fasting blood samples taken at the time of biopsy collection. Results: A positive correlation was seen between the adiponectin concentration within the Sc and V mature adipocytes derived from each child (r = 0.924; P < 0.001). After logarithmic transformation of the Sc and V adiponectin concentrations (log-Sc and log-V) to render the data Gaussian, both log-Sc and log-V were found to be lower in those children with higher body mass index sd score (r = -0.621 and r = -0.357 respectively), although this reached statistical significance only in the Sc adipocytes (P = 0.03). Age was not related to either log-Sc or log-V adiponectin levels, although a significant negative association was seen with serum adiponectin (r = -0.589; P = 0.04). Log-Sc or log-V did not correlate with serum adiponectin concentrations, markers of insulin sensitivity, or circulating lipid levels. Conclusions: These data indicate a relationship between total adiponectin levels in different tissue compartments, suggesting either some form of interaction or coregulation by systemic factors, possibly related to body size/fat mass. Serum concentrations of total adiponectin were inversely related to age but showed no relationship with either tissue levels or body mass index sd score. |
| Databáze: | MEDLINE |
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