A novel amino-on CPG-support for the synthesis of 3'-aminoalkylated oligonucleotides.

Autor: Leuck M; Proligo Biochemie GmbH, Georg-Heyken-Str. 14, Hamburg 21149, Germany., Glare R, Zien N, Paul M, Wolter A
Jazyk: angličtina
Zdroj: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2005; Vol. 24 (5-7), pp. 989-92.
DOI: 10.1081/ncn-200059388
Abstrakt: The synthesis of a novel amino-ON CPG support and its application in the synthesis of 3'-aminoalkylated oligonucleotides is reported. The release of oligonucleotides with free 3'-amino groups is accomplished by treatment with concentrated ammonia for 2 h at 55 degrees C.
Databáze: MEDLINE