[Single fraction boost with high dose rate interstitial brachytherapy in conservative treatment of breast carcinoma].

Autor: Beato Tortajada I; Instituto Valenciano de Oncología, C/Profesor Beltrán Báguena 19, 46009 Valencia, Spain., Guinot Rodríguez JL, Arribas Alpuente L, Aguayo Martos M, Carrascosa Pérez M, Tortajada Azcutia M, Escolar Pérez PP, Maroñas Martín M, Chust Vicente M, Mengual Cloquell JL, Pesudo Ayet C, Casaña Giner M
Jazyk: Spanish; Castilian
Zdroj: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2005 Oct; Vol. 7 (9), pp. 404-8.
DOI: 10.1007/BF02716586
Abstrakt: Introduction: We evaluated the effectiveness of interstitial high dose rate brachytherapy as a single fraction boost to the surgical bed in patients with breast cancer undergoing conservative treatment. The comparison was with the alternative of electron boost.
Materials and Methods: Between April 1999 and December 2000, we conducted a prospective study of 84 patients with infiltrative breast carcinoma treated with conservative surgery, with free margins. This was followed by external radiotherapy to the breast of up to 46 Gy and one application of brachytherapy with needles inserted into the surgical bed, and administering 7 Gy to 90% with high dose rate (HDR).
Results: With a mean follow-up of 43 months, only one patient had therapeutic failure in the implant area, and local control was 98.5%. Another patient had a 2nd tumour in a different quadrant and 3 developed metastasis. Survival at 5 years was 98.7%. Acute toxicity was minimal, with excellent or good cosmetic appearance in 95%.
Conclusions: Brachytherapy with high dose rate as single fraction boost in conservative treatment of breast carcinoma is simple, fast, well tolerated, with excellent local control, good cosmetic appearance, and with minimal late-onset toxicity.
Databáze: MEDLINE
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