| Autor: |
Kuntaman K; Airlangga University, Surabaya, Indonesia., Lestari ES, Severin JA, Kershof IM, Mertaniasih NM, Purwanta M, Hadi U, Johnson JR, van Belkum A, Verbrugh HA |
| Jazyk: |
angličtina |
| Zdroj: |
Emerging infectious diseases [Emerg Infect Dis] 2005 Sep; Vol. 11 (9), pp. 1363-9. |
| DOI: |
10.3201/eid1109.041207 |
| Abstrakt: |
In a recent, population-based survey of 3,996 persons in Indonesia, fluoroquinolone (FQ)-resistant Escherichia coli was prevalent in the fecal flora of 6% of patients at hospital admission and 23% of patients at discharge, but not among healthy relatives or patients visiting primary healthcare centers (2%). Molecular typing showed extensive genetic diversity with only limited clonality among isolates. This finding suggests that independent selection of resistant mutants occurs frequently. FQ-resistant isolates exhibited a higher rate of spontaneous mutation, but sparser virulence profiles, than FQ-susceptible isolates from the same population. The resistant isolates belonged predominantly to phylogenetic groups A (57%) and B1 (22%) but also to the moderately virulent group D (20%). Hypervirulent strains from the B2 cluster were underrepresented (1%). Because FQ-resistant E. coli can cause disease, especially nosocomial infections in immunocompromised patients, spread of such strains must be stopped. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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