Mood- and restraint-based antecedents to binge episodes in bulimia nervosa: possible influences of the serotonin system.
| Autor: | Steiger H; Eating Disorders Program, Douglas Hospital, 6875 LaSalle Boulevard, Montreal (Verdun), Quebec, Canada H4H 1R3. stehow@douglas.mcgill.ca, Gauvin L, Engelberg MJ, Ying Kin NM, Israel M, Wonderlich SA, Richardson J |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Psychological medicine [Psychol Med] 2005 Nov; Vol. 35 (11), pp. 1553-62. |
| DOI: | 10.1017/S0033291705005817 |
| Abstrakt: | Background: In bulimic syndromes, binge episodes are thought to be caused by dietary restraint and negative moods. However, as central serotonin (5-hydroxytryptamine: 5-HT) mechanisms regulate appetite and mood, the 5-HT system could be implicated in diet- and mood-based binge antecedents. Method: We used hand-held computers to obtain repeated "online" measurements of eating behaviors, moods, and self-concepts in 21 women with bulimic syndromes, and modeled 5-HT system activity with a measure of platelet [3H]paroxetine-binding density. Results: Mood and self-concept ratings were found to be worse before binge episodes (than at other moments), and cognitive restraint was increased. After binges, mood and self-concept deteriorated further, and thoughts of dieting became more intense. Intriguingly, lower paroxetine-binding density predicted poorer mood and self-concept before a binge, larger post-binge decrements in mood and self-concept, and larger post-binge increases in dietary restraint. Conclusions: Paroxetine binding thus seemed to reflect processes that impacted upon mood-related antecedents to binge episodes, and consequences implicating mood and dietary restraint. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|