Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors.

Autor: Akritopoulou-Zanze I; Abbott, 100 Abbott Park Road, Abbott Park, IL 60044, USA. irini.zanze@abbott.com, Darczak D, Sarris K, Phelan KM, Huth JR, Song D, Johnson EF, Jia Y, Djuric SW
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Jan 01; Vol. 16 (1), pp. 96-9. Date of Electronic Publication: 2005 Oct 10.
DOI: 10.1016/j.bmcl.2005.09.042
Abstrakt: We report the synthesis of kinase targeted libraries based on the thienopyrazole scaffold. Several thienopyrazole analogs have been identified as submicromolar inhibitors of KDR.
Databáze: MEDLINE