Oligonucleotide ligation assay for detection of mutations associated with reverse transcriptase and protease inhibitor resistance in non-B subtypes and recombinant forms of human immunodeficiency virus type 1.

Autor: Vega Y; Area de Patogenia Viral, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain., Pérez-Alvárez L, Delgado E, Muñoz M, Casado G, Carmona R, Sierra M, Vázquez de Parga E, Pinilla M, García V, Medrano L, Contreras G, Thomson M, Nájera R
Jazyk: angličtina
Zdroj: Journal of clinical microbiology [J Clin Microbiol] 2005 Oct; Vol. 43 (10), pp. 5301-4.
DOI: 10.1128/JCM.43.10.5301-5304.2005
Abstrakt: The oligonucleotide ligation assay is a genotypic assay for the detection of resistance-associated mutations to reverse transcriptase and protease inhibitors in human immunodeficiency virus type 1 subtype B. This assay has been modified and developed for non-B subtypes and recombinant strains and has been evaluated with sequencing, resulting in a more sensitive assay than sequencing for non-B subtypes.
Databáze: MEDLINE