Experience with an adult alcohol withdrawal syndrome practice guideline in internal medicine patients.
| Autor: | Stanley KM; Department of Therapeutic Services, Medical University of South Carolina, Charleston, South Carolina 29425, USA. stanleyk@musc.edu, Worrall CL, Lunsford SL, Simpson KN, Miller JG, Spencer AP |
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| Jazyk: | angličtina |
| Zdroj: | Pharmacotherapy [Pharmacotherapy] 2005 Aug; Vol. 25 (8), pp. 1073-83. |
| DOI: | 10.1592/phco.2005.25.8.1073 |
| Abstrakt: | Study Objective: To standardize treatment of alcohol withdrawal syndrome (AWS) in internal medicine patients using an adult AWS practice guideline with a symptom-triggered management approach. Design: Prospective interventional (pilot group) and retrospective (control group). Setting: University teaching hospital. Patients: Thirty-two internal medicine patients identified as being at risk for AWS and treated according to the AWS practice guideline who were compared with 49 internal medicine patients managed with nonstandardized approaches. Intervention: Patients in the pilot group were assessed using the AWS type indicator. They received lorazepam, clonidine, or haloperidol, based on AWS type indicator assessment and adult AWS practice guideline criteria. Measurements and Main Results: Data collected and analyzed were drugs administered to control AWS symptoms, use of sitters and physical restraints, length of hospital stay, and discharge from hospital receiving tapered drug therapy. Pilot patients received 46.6% less benzodiazepine (p=0.001), 20% more clonidine (p=0.01), and 18.2% more haloperidol (p=0.002) than control patients. No drug therapy was required in 19% of pilot patients compared with 2% of controls (p=0.01). Significantly more control (71.4%) than pilot patients (18.8%) were discharged with tapered benzodiazepine therapy (p |
| Databáze: | MEDLINE |
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