[A dynamic model of total chronic heart failure in rats].

Autor: Fedorov VN, Ialtsev AV, Danilova OV, Sidorov AV, Kataev VV
Jazyk: ruština
Zdroj: Patologicheskaia fiziologiia i eksperimental'naia terapiia [Patol Fiziol Eksp Ter] 2005 Jul-Sep (3), pp. 7-9.
Abstrakt: A dynamic model ofbiventricular chronic heart failure (CHF) induced by fractional introduction of silicon oil into the pleural cavity in rats is proposed. Silicon oil led to enlargement of the heart, myocardial hypertrophy of both ventricles, considerable pulmonary and hepatic congestion due to circulatory failure, decreased stroke volume and cardiac output, increased peripheral vascular resistance, changes in the activity of sympathoadrenal system of the heart and blood. The severity of the induced CHF varied with the dose and number of silicon oil administrations.
Databáze: MEDLINE