| Autor: |
Birch HL; UCB Celltech, Granta Park, Great Abington, Cambridge, CB1 6GS, UK., Buckley GM, Davies N, Dyke HJ, Frost EJ, Gilbert PJ, Hannah DR, Haughan AF, Madigan MJ, Morgan T, Pitt WR, Ratcliffe AJ, Ray NC, Richard MD, Sharpe A, Taylor AJ, Whitworth JM, Williams SC |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Dec 01; Vol. 15 (23), pp. 5335-9. Date of Electronic Publication: 2005 Oct 03. |
| DOI: |
10.1016/j.bmcl.2005.06.108 |
| Abstrakt: |
The synthesis and biological activity of a novel series of 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones are described. Some of these compounds were found to be potent inhibitors of inosine 5'-monophosphate dehydrogenase type II (IMPDH II). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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