| Autor: |
Milosević M; Institute of Nuclear Sciences Vinca, Laboratory for Molecular Biology and Endocrinology, Belgrade, Serbia and Montenegro., Petrović S, Demajo M, Horvat A |
| Jazyk: |
angličtina |
| Zdroj: |
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2005 Jun; Vol. 1048, pp. 445-8. |
| DOI: |
10.1196/annals.1342.061 |
| Abstrakt: |
The in vitro effects of cadmium and mercury were investigated on the Mg(2+)-ATPase activity of plasma membranes from the rat ovary and uterus. ATP hydrolyzing activities were significant and dose-dependent-inhibited in both plasma membrane preparations by both metals. According to the IC(50) and apparent K(i), Cd(2+) was most potent in the ovary, while Hg(2+) was most potent in the uterus. In ovaries and uterus, Cd(2+) inhibits competitively, while Hg(2+) inhibits noncompetitively in both organs. The observed inhibition was a consequence of direct action of the chosen metal ions on the enzyme protein and by decreasing ATP hydrolysis, Hg(2+) and Cd(2+) may affect mammalian fertility. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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