Myocardial contractility is early affected in systemic sclerosis: a tissue Doppler echocardiography study.

Autor:	Meune C; Department of Cardiology, Cochin Hospital, AP-HP, René Descartes University, 27 rue du Fg St-Jacques, 75014 Paris, France. christophe.meune@cch.ap-hop-paris.fr, Allanore Y, Pascal O, Devaux JY, Dessault O, Duboc D, Weber S, Kahan A
Jazyk:	angličtina
Zdroj:	European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology [Eur J Echocardiogr] 2005 Oct; Vol. 6 (5), pp. 351-7. Date of Electronic Publication: 2005 Feb 25.
DOI:	10.1016/j.euje.2004.12.006
Abstrakt:	Aims: Systemic sclerosis (SSc) is a connective tissue disorder characterized by frequent myocardial involvement. Alteration in left ventricular (LV) function is reported to be rare; however, it may be underestimated by conventional measurements. Our aim was to prospectively investigate LV function in SSc patients, using Tissue Doppler echocardiography (TDE), a modern and accurate method of assessing myocardial function. Methods and Results: Seventeen consecutive SSc patients with normal cardiac examination, pulmonary artery pressure (PAP) and radionuclide LV ejection fraction (EF) were prospectively investigated. Myocardial perfusion was investigated using single-photon-emission computerized tomography (SPECT). Echocardiography (ECHO), systolic and diastolic strain-rate (SR) measured in the posterior wall by TDE were used to investigate myocardial function, and compared with results of 15 matched controls. All patients (53+/-8 years; 14 women; systolic PAP 33+/-6 mmHg; LVEF 67+/-8%) had myocardial SPECT perfusion abnormalities. Despite normal ECHO, they had lower systolic SR than controls (1.7+/-0.5 versus 3.8+/-1.7 cm-1, p<0.0001), and lower diastolic SR (3.7+/-1.5 versus 5.6+/-1.2 cm-1, p=0.0004). Ten SSc patients had reduced systolic SR<1.7 cm-1 and 11 reduced diastolic SR<3.5 cm-1. Conclusion: Frequent abnormal myocardial perfusion is confirmed in SSc patients. Reduced contractility is also frequent as detected by TDE, despite normal radionuclide LVEF.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu